Australian-born Samantha Noble isn't the only person in her family who is in the media. Her father is actor/director John Noble, of "Lord of the Rings" fame. Samantha is a trained High School teacher. She completed her Masters at Sydney University in 2004 and then decided, after graduation, she wanted to be an actor. She has trained at NIDA, Actors Studio in New York, Stella Adler Institute in Los Angeles, Ivana Chubbuck Studio, On Camera Connections and ATYP.

She has starred in Court of Lonely Royals (2006), Hildegard (1983), See No Evil (2006), All Saints (1998), Home and Away (1988), Life Support (1999), Water Rats (1996), Nailed (2007) and Gabriel (2007). She has also starred in many short-films, including $100 Taxi Ride (2001), How To Hurt (2000), Lost Little Girl (2007) and Dead Man's Creek (2000). As well as being an actress, Samantha is also a professional singer, director and writer. She teaches acting at numerous film schools in Sydney and Los Angeles. She plays the piano and saxophone.

She has a brother, Daniel, and a sister, Jessica. Jessica is a professional model; Daniel is a graphic artist.

Samantha resides in Los Angeles and is also a professional model.